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Vet Pathol. 2015 Jan;52(1):224-9. doi: 10.1177/0300985814528218. Epub 2014 Mar 31.

Malformation of incisor teeth in Grem2⁻/⁻ mice.

Author information

  • 1Department of Pathology, Lexicon Pharmaceuticals Inc, The Woodlands, TX, USA peter.vogel@stjude.org.
  • 2Department of Metabolism, Lexicon Pharmaceuticals Inc, The Woodlands, TX, USA.
  • 3Department of Molecular Genetics, Lexicon Pharmaceuticals Inc, The Woodlands, TX, USA.
  • 4Department of Pathology, Lexicon Pharmaceuticals Inc, The Woodlands, TX, USA.

Abstract

GREMLIN 2 (GREM2)--formerly, protein related to Dan and cerberus (PRDC)-is a potent antagonist of the bone morphogenetic proteins 2 and 4, but little else in known about its functions. We found that Grem2(-/-) mice developed small deformed mandibular and maxillary incisors, indicating that GREMLIN2 is required for normal tooth morphogenesis. Although DEXA scans suggested that bone mineral density might be increased in Grem2(-/-) mice, histology did not reveal any evident bone phenotype. Grem2(-/-) mice did not display any other notable phenotypes evaluated in a high-throughput screening process that encompassed a range of immunologic, metabolic, ophthalmic, and behavioral parameters. Our findings indicate that Grem2 can be added to the growing list of genes that affect tooth development in mice.

KEYWORDS:

Gremlin; bone morphogenetic protein; cusp; incisor; microdontia; molar; tooth

PMID:
24686385
DOI:
10.1177/0300985814528218
[PubMed - indexed for MEDLINE]
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