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Neuroreport. 2014 May 28;25(8):549-55. doi: 10.1097/WNR.0000000000000130.

BMP2 shows neurotrophic effects including neuroprotection against neurodegeneration.

Author information

1
aTissueGene Inc., Rockville, Maryland, USA bDepartment of Orthopedic Surgery, Gil Medical Center, Gachon University, Incheon cDepartment of Orthopedics, The Uniformed Force Capital Hospital, Kyunggido, Republic of Korea.

Abstract

In this study, we found that BMP2 exerts neurotrophic effects, including a neuroprotective effect against nocodazole-induced neuritic degeneration, on neuronal cells. We also found that BMP2-induced neurotrophic effects are directly involved in Smad-dependent signaling as well as PI3K/PTEN-Akt-mTOR signaling. Moreover, BMP2-induced neurotrophic effects occur by stabilization of neuronal microtubules. Thus, these findings suggest that BMP2 can be a potential therapeutic target for nerve injury treatment.

PMID:
24686133
DOI:
10.1097/WNR.0000000000000130
[Indexed for MEDLINE]

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