Format

Send to

Choose Destination
Transl Res. 2015 Jan;165(1):74-90. doi: 10.1016/j.trsl.2014.03.001. Epub 2014 Mar 12.

Epigenetics of lung cancer.

Author information

1
Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio.
2
Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minn.
3
Department of Epidemiology, Brown University, Providence, RI; Department of Pathology and Laboratory Medicine, Brown University, Providence, RI. Electronic address: karl_kelsey@brown.edu.

Abstract

Lung cancer is the leading cause of cancer-related mortality in the United States. Epigenetic alterations, including DNA methylation, histone modifications, and noncoding RNA expression, have been reported widely in the literature to play a major role in the genesis of lung cancer. The goal of this review is to summarize the common epigenetic changes associated with lung cancer to give some clarity to its etiology, and to provide an overview of the potential translational applications of these changes, including applications for early detection, diagnosis, prognostication, and therapeutics.

PMID:
24686037
PMCID:
PMC4162853
DOI:
10.1016/j.trsl.2014.03.001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center