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Food Chem Toxicol. 2014 Jun;68:290-6. doi: 10.1016/j.fct.2014.03.026. Epub 2014 Mar 29.

Anti-fatigue and vasoprotective effects of quercetin-3-O-gentiobiose on oxidative stress and vascular endothelial dysfunction induced by endurance swimming in rats.

Author information

1
The Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, Lin'an 311300, China; School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
2
The Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, Lin'an 311300, China.
3
Zhejiang Academy of Medical Sciences, Hangzhou 310013, China; Zhejiang Chinese Medical University, Hangzhou 310053, China.
4
Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
5
Zhejiang Chinese Medical University, Hangzhou 310053, China.
6
The Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, Lin'an 311300, China. Electronic address: yuan_ke001@126.com.

Abstract

Chronic fatigue accumulation increases the incidence of cardiovascular disease while the treatment of antioxidants could prevent this development. We have previously shown that quercetin-3-O-gentiobiose (QG), a flavonoid isolated from tonic herb Okra, possesses anti-oxidative properties. In the present study, the protective effects of QG were evaluated in a rat model of load-induced endurance swimming. Oral administration of QG at the doses of 25-75mg/kg could significantly improve the endurance capability of rats to fatigue along with decrease serum lactic acid and blood urea nitrogen levels were decreased. Moreover, QG could alleviate vascular impairments, enhance the activities of antioxidant enzymes and attenuate the levels of inflammatory cytokines (MCP-1, IL-6 and TNF-α). The results indicated that QG had anti-fatigue and vasoprotective effects and represented a potential agent for the treatment of aortic pathology involved with fatigue- and related syndrome.

KEYWORDS:

Antioxidant; Fatigue; Flavonoid; Oxidative stress; Vascular endothelial dysfunction

PMID:
24685824
DOI:
10.1016/j.fct.2014.03.026
[Indexed for MEDLINE]

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