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Dev Comp Immunol. 2014 Sep;46(1):63-73. doi: 10.1016/j.dci.2014.03.010. Epub 2014 Mar 29.

Perspectives on antigen presenting cells in zebrafish.

Author information

1
Division of Biological Sciences, University of California, San Diego, La Jolla, CA, United States.
2
Division of Biological Sciences, University of California, San Diego, La Jolla, CA, United States. Electronic address: dtraver@ucsd.edu.

Abstract

Antigen presentation is a critical step in the activation of naïve T lymphocytes. In mammals, dendritic cells (DCs), macrophages, and B lymphocytes can all function as antigen presenting cells (APCs). Although APCs have been identified in zebrafish, it is unclear if they fulfill similar roles in the initiation of adaptive immunity. Here we review the characterization of zebrafish macrophages, DCs, and B cells and evidence of their function as true APCs. Finally, we discuss the conservation of APC activity in vertebrates and the use of zebrafish to provide a new perspective on the evolution of these functions.

KEYWORDS:

Antigen-presenting cells; B lymphocytes; Dendritic cells; Macrophages; Zebrafish

PMID:
24685511
PMCID:
PMC4158852
DOI:
10.1016/j.dci.2014.03.010
[Indexed for MEDLINE]
Free PMC Article

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