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Cell Rep. 2014 Apr 10;7(1):113-26. doi: 10.1016/j.celrep.2014.02.044. Epub 2014 Mar 27.

A histone methylation network regulates transgenerational epigenetic memory in C. elegans.

Author information

1
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Division of Newborn Medicine, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA.
2
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
3
Division of Newborn Medicine, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA.
4
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
5
Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
6
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Division of Newborn Medicine, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address: yshi@hms.harvard.edu.

Abstract

How epigenetic information is transmitted from generation to generation remains largely unknown. Deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase spr-5 leads to inherited accumulation of the euchromatic H3K4me2 mark and progressive decline in fertility. Here, we identified multiple chromatin-modifying factors, including H3K4me1/me2 and H3K9me3 methyltransferases, an H3K9me3 demethylase, and an H3K9me reader, which either suppress or accelerate the progressive transgenerational phenotypes of spr-5 mutant worms. Our findings uncover a network of chromatin regulators that control the transgenerational flow of epigenetic information and suggest that the balance between euchromatic H3K4 and heterochromatic H3K9 methylation regulates transgenerational effects on fertility.

PMID:
24685137
PMCID:
PMC4012616
DOI:
10.1016/j.celrep.2014.02.044
[Indexed for MEDLINE]
Free PMC Article

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