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Neurobiol Aging. 2014 Aug;35(8):1957.e9-1957.e14. doi: 10.1016/j.neurobiolaging.2014.03.002. Epub 2014 Mar 5.

Serotonin transporter polymorphic region 5-HTTLPR modulates risk for Parkinson's disease.

Author information

1
Department of Geriatrics & Neurology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
2
Department of Preventive Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
3
Department of Geriatrics & Neurology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China; Department of Preventive Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: jianhong.zhu@gmail.com.

Abstract

The association between the serotonin transporter gene (SLC6A4) polymorphisms, that is, 5-HTTLPR and rs25531, and Parkinson's disease (PD) remains to be further defined. We investigated this relationship in a Chinese cohort that comprised 504 PD patients and 504 controls. A total of 8 haplotypes and 14 genotypes of SLC6A4 were found in this population including a new variant of 5-HTTLPR, that is, 20G. Our results presented that 5-HTTLPR was associated with an aggravated risk for PD (p = 0.005). The rs25531 alone is not associated with PD susceptibility. However, in a sub-classification based on the impact of 5-HTTLPR and rs25531 on 5-HTT expression, we observed a significant difference in 5-HTT expressing distribution in the cohort, accompanied by an apparently lower level of 5-HTT high expressing group, that is, the LALA genotype, in the PD patients. Taken together, our data provide novel insight in support that the SLC6A4 polymorphisms, particularly 5-HTTLPR, and the serotonergic system are associated with PD etiology.

KEYWORDS:

5-HTTLPR; Parkinson's disease; Polymorphism; Serotonin transporter; rs25531

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