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Clin Pharmacol Ther. 2014 Aug;96(2):206-13. doi: 10.1038/clpt.2014.70. Epub 2014 Mar 28.

Using positron emission tomography to study transporter-mediated drug-drug interactions in tissues.

Author information

1
Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
2
Health and Environment Department, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.
3
1] Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria [2] Health and Environment Department, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.

Abstract

Drug disposition is highly regulated by membrane transporters. Some transporter-mediated drug-drug interactions (DDIs) may not manifest themselves in changes in systemic exposure but rather in changes in tissue exposure of drugs. To better assess the impact of transporter-mediated DDIs in tissues, positron emission tomography (PET)-a noninvasive imaging method--plays an increasingly important role. In this article, we provide examples of how PET can be used to assess transporter-mediated DDIs in different organs.

PMID:
24682030
PMCID:
PMC4153445
DOI:
10.1038/clpt.2014.70
[Indexed for MEDLINE]
Free PMC Article
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