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Nat Struct Mol Biol. 2014 Apr;21(4):423-5. doi: 10.1038/nsmb.2799. Epub 2014 Mar 30.

The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity.

Author information

1
Gene Regulation Laboratory, Genome Institute of Singapore, Singapore.
2
1] Gene Regulation Laboratory, Genome Institute of Singapore, Singapore. [2] Department of Biochemistry, National University of Singapore, Singapore.
3
Department of Human Genetics, McGill University, Montréal, Québec, Canada.
4
1] Gene Regulation Laboratory, Genome Institute of Singapore, Singapore. [2] Département de Biologie, Université de Sherbrooke, Sherbrooke, Québec, Canada.
5
1] Department of Human Genetics, McGill University, Montréal, Québec, Canada. [2] Génome Québec Innovation Center, McGill University, Montréal, Québec, Canada.
6
1] Gene Regulation Laboratory, Genome Institute of Singapore, Singapore. [2] Department of Biochemistry, National University of Singapore, Singapore. [3] Department of Biological Sciences, National University of Singapore, Singapore. [4] School of Biological Sciences, Nanyang Technological University, Singapore.

Abstract

Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear long noncoding RNA required to maintain hESC identity. Furthermore, HERVH is associated with OCT4, coactivators and Mediator subunits. Together, these results uncover a new role of species-specific transposable elements in hESCs.

PMID:
24681886
DOI:
10.1038/nsmb.2799
[Indexed for MEDLINE]

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