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Acta Biochim Biophys Sin (Shanghai). 2014 Jun;46(6):431-40. doi: 10.1093/abbs/gmu019. Epub 2014 Mar 28.

Prion protein and cancers.

Author information

1
Department of the First Abdominal Surgery, Jiangxi Tumor Hospital, Nanchang 330029, China.
2
Department of Molecular Endocrinology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
3
Department of Pathology, Zhongda Hospital, Southeast University, Nanjing 210009, China.
4
Department of General Surgery, Changhai Hospital of Second Military Medical University, Shanghai 200433, China.
5
Department of Stomatology, The First Affiliated Hospital of Shihezi University Medical College, Shihezi 832000, China.
6
State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China cyli@wh.iov.cn.

Abstract

The normal cellular prion protein, PrP(C) is a highly conserved and widely expressed cell surface glycoprotein in all mammals. The expression of PrP is pivotal in the pathogenesis of prion diseases; however, the normal physiological functions of PrP(C) remain incompletely understood. Based on the studies in cell models, a plethora of functions have been attributed to PrP(C). In this paper, we reviewed the potential roles that PrP(C) plays in cell physiology and focused on its contribution to tumorigenesis.

KEYWORDS:

prion disease; prion protein; tumorigenesis

PMID:
24681883
DOI:
10.1093/abbs/gmu019
[Indexed for MEDLINE]

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