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Nat Nanotechnol. 2014 May;9(5):397-404. doi: 10.1038/nnano.2014.38. Epub 2014 Mar 30.

Multifunctional wearable devices for diagnosis and therapy of movement disorders.

Author information

1
1] Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea [2] School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea [3].
2
Center for Mechanics of Solids, Structures and Materials, Department of Aerospace Engineering and Engineering Mechanics, Texas Materials Institute, University of Texas at Austin, 210 E 24th Street, Austin, Texas 78712, USA.
3
MC10 Inc., 9 Camp Street, Cambridge, Massachusetts 02140, USA.
4
1] Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea [2] School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
5
WCU Hybrid Materials Program, Department of Materials Science and Engineering and Inter-university Semiconductor Research Center, Seoul National University, Seoul 151-744, Republic of Korea.

Abstract

Wearable systems that monitor muscle activity, store data and deliver feedback therapy are the next frontier in personalized medicine and healthcare. However, technical challenges, such as the fabrication of high-performance, energy-efficient sensors and memory modules that are in intimate mechanical contact with soft tissues, in conjunction with controlled delivery of therapeutic agents, limit the wide-scale adoption of such systems. Here, we describe materials, mechanics and designs for multifunctional, wearable-on-the-skin systems that address these challenges via monolithic integration of nanomembranes fabricated with a top-down approach, nanoparticles assembled by bottom-up methods, and stretchable electronics on a tissue-like polymeric substrate. Representative examples of such systems include physiological sensors, non-volatile memory and drug-release actuators. Quantitative analyses of the electronics, mechanics, heat-transfer and drug-diffusion characteristics validate the operation of individual components, thereby enabling system-level multifunctionalities.

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PMID:
24681776
DOI:
10.1038/nnano.2014.38
[Indexed for MEDLINE]
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