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J Photochem Photobiol B. 2014 Apr 5;133:47-54. doi: 10.1016/j.jphotobiol.2014.02.019. Epub 2014 Mar 12.

Anti-inflammatory and antioxidant effects of Aloe saponaria Haw in a model of UVB-induced paw sunburn in rats.

Author information

1
Programa de Pós Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria (UFSM), 97109-900 Santa Maria, RS, Brazil; Departamento de Saúde, Curso de Biomedicina, Faculdade de Educação e Cultura de Vilhena, 76980-000 Vilhena, RO, Brazil.
2
Programa de Pós Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria (UFSM), 97109-900 Santa Maria, RS, Brazil; Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense (UNESC), 88806-000, Criciúma, SC, Brazil.
3
Programa de Pós-graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), 97109-900 Santa Maria, RS, Brazil; Departamento de Saúde, Curso de Biomedicina, Faculdade de Educação e Cultura de Vilhena, 76980-000 Vilhena, RO, Brazil.
4
Programa de Pós Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria (UFSM), 97109-900 Santa Maria, RS, Brazil.
5
Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria (UFSM), 97109-900 Santa Maria, RS, Brazil.
6
Departamento de Saúde, Curso de Farmácia, Universidade Federal de Sergipe (UFS), 49400-000 Lagarto, SE, Brazil.
7
Programa de Pós Graduação em Atenção Integral à Saúde, Universidade de Cruz Alta, 98020-290 Cruz Alta, RS, Brazil.
8
Programa de Pós Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria (UFSM), 97109-900 Santa Maria, RS, Brazil; Programa de Pós-graduação em Farmacologia, Universidade Federal de Santa Catarina (UFSC), 88049-900 Florianópolis, SC, Brazil. Electronic address: ferreiraj99@gmail.com.

Abstract

Ultraviolet B (UVB) irradiation mainly affects biological tissues by inducing an increase in reactive oxygen species (ROS) production which leads to deleterious outcomes for the skin, including pain and inflammation. As a protective strategy, many studies have focused on the use of natural products. The aim of this study was to investigate the effects of Aloe saponaria on nociceptive, inflammatory, and oxidative parameters in a model of UVB-induced sunburn in adult male Wistar rats. Sunburned animals were topically treated with vehicle (base cream), 1% silver sulfadiazine (positive control) or A. saponaria (10%) once a day for 6days. UVB-induced nociception (allodynia and hyperalgesia), inflammation (edema and leukocyte infiltration) and oxidative stress (increases in H2O2, protein carbonyl levels and lipid peroxidation and a decrease in non protein thiol content) were reduced by both A. saponaria and sulfadiazine topical treatment. Furthermore, A. saponaria or its constituents aloin and rutin reduced the oxidative stress induced by H2O2 in skin homogenates in vitro. Our results demonstrate that topical A. saponaria treatment displayed anti-nociceptive and anti-inflammatory effects in a UVB-induced sunburn model, and these effects seem to be related to its antioxidant components.

KEYWORDS:

Aloin; Analgesic; Anti-inflammatory; Antioxidant; Rutin; Silver sulfadiazine

[Indexed for MEDLINE]

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