Format

Send to

Choose Destination
Sci Rep. 2014 Mar 31;4:4530. doi: 10.1038/srep04530.

Meta-analysis of infectious agents and depression.

Author information

1
1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3].
2
1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [4].
3
1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
4
1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China.

Abstract

Depression is a debilitating psychiatric disorder and a growing global public health issue. However, the relationships between microbial infections and depression remains uncertain. A computerized literature search of Medline, ISI Web of Knowledge, PsycINFO, and the Cochrane Library was conducted up to May 2013, and 6362 studies were initially identified for screening. Case-control studies detected biomarker of microorganism were included. Based on inclusion and exclusion criteria, 28 studies were finally included to compare the detection of 16 infectious agents in unipolar depressed patients and healthy controls with a positive incident being defined as a positive biochemical marker of microbial infection. A customized form was used for data extraction. Pooled analysis revealed that the majority of the 16 infectious agents were not significantly associated with depression. However, there were statistically significant associations between depression and infection with Borna disease virus, herpes simplex virus-1, varicella zoster virus, Epstein-Barr virus, and Chlamydophila trachomatis.

PMID:
24681753
PMCID:
PMC5380112
DOI:
10.1038/srep04530
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center