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Curr Opin Immunol. 2014 Jun;28:90-6. doi: 10.1016/j.coi.2014.02.010. Epub 2014 Mar 27.

Clonal and cellular dynamics in germinal centers.

Author information

1
Whitehead Institute for Biomedical Research, Cambridge, USA. Electronic address: victora@wi.mit.edu.
2
Whitehead Institute for Biomedical Research, Cambridge, USA.

Abstract

Germinal centers (GCs) are the site of antibody affinity maturation, a process that involves complex clonal and cellular dynamics. Selection of B cells bearing higher-affinity immunoglobulins proceeds via a stereotyped pattern whereby B cells migrate cyclically between the GC's two anatomical compartments. This process occurs in a timeframe that is well suited to analysis by intravital microscopy, and much has been learned in recent years by use of these techniques. On a longer time scale, the diversity of B cell clones and variants within individual GCs is also thought to change as affinity maturation progresses; however, our understanding of clonal dynamics in individual GCs is limited. We discuss recent progress in the elucidation of clonal and cellular dynamics patterns.

PMID:
24681449
PMCID:
PMC4037377
DOI:
10.1016/j.coi.2014.02.010
[Indexed for MEDLINE]
Free PMC Article
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