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Curr Opin Cell Biol. 2014 Aug;29:18-24. doi: 10.1016/j.ceb.2014.02.005. Epub 2014 Mar 25.

The protein-vesicle network of autophagy.

Author information

1
Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, United States.
2
Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720, United States.
3
Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720, United States. Electronic address: jimhurley@berkeley.edu.

Abstract

The biogenesis of autophagosomes entails the nucleation and growth of a double-membrane sheet, the phagophore, which engulfs cytosol for delivery to the lysosome. Genetic studies have identified a class of Atg proteins that are essential for the process, yet the molecular mechanism of autophagosome biogenesis has been elusive. Proteomic, structural, super-resolution imaging, and biochemical reconstitution experiments have begun to fill in some of the gaps. This review describes progress and prospects for obtaining a four-dimensional network model of the nucleation and growth of the phagophore.

PMID:
24681112
DOI:
10.1016/j.ceb.2014.02.005
[Indexed for MEDLINE]

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