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Int J Biol Macromol. 2014 Jun;67:336-42. doi: 10.1016/j.ijbiomac.2014.03.031. Epub 2014 Mar 27.

A study of neuroprotective and antioxidant activities of heteropolysaccharides from six Sargassum species.

Author information

1
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China; Nantong Branch, Institute of Oceanology, Chinese Academy of Sciences, Nantong 226006, Jiangsu, PR China. Electronic address: jinweihua09@mails.ucas.ac.cn.
2
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
3
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China; Nantong Branch, Institute of Oceanology, Chinese Academy of Sciences, Nantong 226006, Jiangsu, PR China.
4
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China.
5
Fisheries College, Guangdong Ocean University, Zhanjiang 524025, PR China.
6
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China. Electronic address: qbzhang@ms.qdio.ac.cn.

Abstract

Heteropolysaccharides were extracted from Sargassum integerrimum (S.I), Sargassum maclurei (S.M), Sargassum naozhouense (S.N), Spiraea thunbergii (S.T), Sargassum hemiphyllum (S.H) and Sargassum fusiforme (S.F), and their neuroprotective effects and antioxidant activities were investigated. It showed that S.I, S.N, S.T and S.F exhibited neuroprotective activities, whereas S.H and S.M did not. For this reason, they were separated by anion-exchange chromatography. It was apparent that the fraction 2 represented the principal difference between the active and non-active compounds. However, it did not correlate with neuroprotective effect. In addition, the results on antioxidant activities showed that the hydroxyl-radical scavenging effect contribute to the neuroprotective effect of S.T and S.N, and the DPPH-radical scavenging effect and reducing power contribute to S.T, S.F and S.I. However, the superoxide-radical scavenging effect did not correlate with neuroprotective activity. The conclusion was that the neuroprotective activity of the family of compounds investigated depended on a variety of factors.

KEYWORDS:

Antioxidant activity; Neuroprotective activity; Sargassum

PMID:
24680812
DOI:
10.1016/j.ijbiomac.2014.03.031
[Indexed for MEDLINE]

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