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Trends Immunol. 2014 Jun;35(6):262-9. doi: 10.1016/j.it.2014.02.008. Epub 2014 Mar 26.

The immunomodulating role of exercise in metabolic disease.

Author information

1
Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia. Electronic address: graeme.lancaster@bakeridi.edu.au.
2
Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia. Electronic address: mark.febbraio@bakeridi.edu.au.

Abstract

A lack of physical activity is linked to the development of many chronic diseases. It is now well established that the immune system and inflammation play a central role in the development of numerous chronic metabolic diseases including insulin resistance, type 2 diabetes, atherosclerosis, nonalcoholic fatty liver disease, and specific types of cancer. Physical exercise elicits potent anti-inflammatory effects that are likely to account for many of the salutary actions of regular exercise on chronic metabolic diseases. Here we review the anti-inflammatory and immunomodulatory mechanisms by which the beneficial effects of exercise on chronic metabolic diseases may be mediated.

KEYWORDS:

anti-inflammatory; exercise; immune cells; inflammation; metabolic disease; muscle

PMID:
24680647
DOI:
10.1016/j.it.2014.02.008
[Indexed for MEDLINE]

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