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Phytomedicine. 2014 Jun 15;21(7):966-9. doi: 10.1016/j.phymed.2014.02.010. Epub 2014 Mar 26.

Gastroprotective effect of epoxy clerodane diterpene isolated from Tinospora cordifolia Miers (Guduchi) on indomethacin-induced gastric ulcer in rats.

Author information

1
Department of Veterinary Physiology, College of Veterinary Medicine, Chonbuk National University, Biosafety Research Institute, 664-14, 1GA, Duckjin-Dong, Duckjin-Gu, Jeonju City, Jeollabuk-Do 561-756, Republic of Korea.
2
Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, Tamil Nadu, India.
3
Department of Botany and Microbiology, College of Science, King Saud University, PO Box No. 2455, Riyadh 11451, Saudi Arabia.
4
Department of Plant Biology and Biotechnology, Loyola College, Chennai 600 034, Tamil Nadu, India.
5
Department of Veterinary Physiology, College of Veterinary Medicine, Chonbuk National University, Biosafety Research Institute, 664-14, 1GA, Duckjin-Dong, Duckjin-Gu, Jeonju City, Jeollabuk-Do 561-756, Republic of Korea. Electronic address: jhkim1@jbnu.ac.kr.

Abstract

The present study evaluated the gastroprotective effect of epoxy clerodane diterpene (ECD), isolated from Tinospora cordifolia on indomethacin-induced gastric ulcer in rats. Administration of indomethacin exhibits extreme levels of ulcer index (UI) and myeloperoxidase (MPO) activity. Indomethacin down regulated PGE2, anti-inflammatory cytokines (IL-4, IL-10) and pro-angiogenic factors (VEGF and EGF). The ECD pretreatment considerably increased the levels of PGE2, anti-inflammatory cytokines and pro-angiogenic factors. The ulcer-healing activity of ECD was inhibited by pre-administration of the specific COX-1 inhibitor (SC560) and nonspecific NOS inhibitor (L-NAME), which indicates the involvement of PGE2 and NOS in ECD induced ulcer healing activity. These findings suggest that ECD exerts its antiulcer activity by reinforcement of defensive elements and diminishing the offensive elements.

KEYWORDS:

Antiulcer; Epoxy clerodane diterpene; Gastric ulcer; Tinospora cordifolia; Ulcer index

PMID:
24680619
DOI:
10.1016/j.phymed.2014.02.010
[Indexed for MEDLINE]

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