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Urology. 2014 May;83(5):1205.e1-5. doi: 10.1016/j.urology.2014.01.015. Epub 2014 Mar 25.

Assessment of intrarenal oxygenation in renal donor with blood oxygenation level-dependent magnetic resonance imaging.

Author information

1
Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
2
Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
3
Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address: liangrenliu@126.com.

Abstract

OBJECTIVE:

To examine change of the apparent relaxation rate R2* values in living kidney donors after uninephrectomy using blood oxygenation level-dependent magnetic resonance imaging.

METHODS:

Between July 2011 and January 2012, 45 kidney donors were enrolled into this study. Blood oxygenation level-dependent magnetic resonance imaging scanning was performed before surgery, 3 and 7 days postoperatively. Participants were followed up for 1 year.

RESULTS:

The R2* values in medulla (mR2*) were significantly greater than that of cortex (cR2*), both in resected kidney and remaining one. cR2* values of the remaining kidney was 17.52 ± 1.36 s(-1) and then decrease significantly by 8.97% to 15.95 ± 1.14 s(-1) at 3 days (P <.001) and by 7.82% to 16.15 ± of 1.05 s(-1) at 7 days. No significant modification occurred in mR2* after surgery. Multivariate regression analysis showed that the decrease in cR2* values of the remaining kidney was positively associated with sex (r = 0.418), body surface area (r = 0.307), and preoperative cR2* values (r = 0.659). Comparing with glomerular filtration rate at 7 days, a further increment in the glomerular filtration rate was noted at 1 year in patients with cR2* values decrease of ≥ 10% at 1 week (62.63 ± 11.69 vs 56.97 ± 7.51 mL/min/1.73 m(2), P = .02) but not in the other patients (66.43 ± 10.89 vs 62.78 ± 13.74, P = .064).

CONCLUSION:

Kidney donation will induce early, profound oxygenation modification within the renal cortex of the remaining kidney. Donors with cR2* value decrease of ≥ 10% at 1 week have a more favorable renal function compensation at 1 year.

PMID:
24680611
DOI:
10.1016/j.urology.2014.01.015
[Indexed for MEDLINE]
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