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Sleep Med. 2014 Apr;15(4):436-43. doi: 10.1016/j.sleep.2014.01.014. Epub 2014 Feb 15.

The association of somatic arousal with the symptoms of upper airway resistance syndrome.

Author information

1
Department of Psychiatry and Behavioral Sciences, Stony Brook University School of Medicine, Stony Brook, NY 11794, USA.
2
Novartis Consumer Health, Parsippany, NJ 07054, USA.
3
Division of Pulmonary/Critical Care/Sleep Medicine, Stony Brook University School of Medicine, Stony Brook, NY 11794, USA; DVA Medical Center, Northport, NY 11768, USA.
4
Division of Pulmonary/Critical Care/Sleep Medicine, Stony Brook University School of Medicine, Stony Brook, NY 11794, USA; DVA Medical Center, Northport, NY 11768, USA. Electronic address: avram.gold@va.gov.

Abstract

OBJECTIVES:

We tested the hypothesis that the symptoms of upper airway resistance syndrome (UARS) are manifestations of chronic stress. To accomplish this, we utilized the score on a self-report questionnaire for somatic arousal (a component of stress) to compare somatic arousal between UARS patients and healthy controls and, among all participants, to correlate the level of somatic arousal with the severity of UARS symptoms.

METHODS:

We administered the Mood and Anxiety Symptom Questionnaire anxious arousal subscale (MASQaas; a 17-item questionnaire with increasing levels of arousal scored 17-85) to 12 UARS patients and 12 healthy controls and compared scores between groups. For all participants, we correlated the MASQaas scores with scores for the Epworth Sleepiness Scale (ESS), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) scale, Pittsburgh Sleep Quality Index (PSQI), SF-36 Health Survey, and Perceived Deficits Questionnaire (PDQ; assessing cognitive function).

RESULTS:

Compared to healthy controls, UARS patients demonstrated increased somatic arousal (MASQaas scores of 18±2 and 28±7, respectively; p<0.0001). For all participants, the MASQaas scores correlated significantly with scores of the ESS (r=0.64; p=0.0008), the FACIT-Fatigue scale (r=-0.89; p<0.0001), the PSQI (r=0.70; p=0.0002), SF-36 Physical component (r=-0.78; p<0.0001), SF-36 Mental component (r=-0.74; p<0.0001), and the PDQ (r=0.89; p<0.0001).

CONCLUSIONS:

Our findings suggest that UARS patients have increased levels of the stress component, somatic arousal, proportionate to the severity of their symptoms.

KEYWORDS:

Central sensitization syndromes; Chronic stress; Sleep-disordered breathing; Somatic arousal; Sympathetic nervous system; Upper airway resistance syndrome

PMID:
24680565
DOI:
10.1016/j.sleep.2014.01.014
[Indexed for MEDLINE]

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