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Curr Opin Cell Biol. 2014 Apr;27:109-16. doi: 10.1016/j.ceb.2013.10.003. Epub 2013 Dec 28.

GPCR signaling along the endocytic pathway.

Author information

1
Department of Psychiatry, University of California, San Francisco School of Medicine, 600 16th Street, San Francisco, CA 94158-2140, USA; Department of Cellular & Molecular Pharmacology, University of California, San Francisco School of Medicine, 600 16th Street, San Francisco, CA 94158-2140, USA.
2
Department of Psychiatry, University of California, San Francisco School of Medicine, 600 16th Street, San Francisco, CA 94158-2140, USA; Department of Cellular & Molecular Pharmacology, University of California, San Francisco School of Medicine, 600 16th Street, San Francisco, CA 94158-2140, USA. Electronic address: mark.vonzastrow@ucsf.edu.

Abstract

Many G protein-coupled receptors (GPCRs) internalize after agonist-induced activation. While endocytosis has long been associated with homeostatic attenuation of cellular responsiveness, accumulating evidence from study of a wide range of eukaryotes reveals that the endocytic pathway also contributes to generating receptor-initiated signals themselves. Here we review recent progress in this area, discussing primarily but not exclusively GPCR signaling in mammalian cells.

PMID:
24680436
PMCID:
PMC4968408
DOI:
10.1016/j.ceb.2013.10.003
[Indexed for MEDLINE]
Free PMC Article
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