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J Subst Abuse Treat. 2014 Jul;47(1):27-34. doi: 10.1016/j.jsat.2014.02.003. Epub 2014 Mar 3.

Abuse and diversion of buprenorphine sublingual tablets and film.

Author information

1
Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, 777 Bannock Street, MC 0180, Denver, CO, 80204, USA. Electronic address: eric.lavonas@rmpdc.org.
2
Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, 777 Bannock Street, MC 0180, Denver, CO, 80204, USA. Electronic address: geoff.severtson@rmpdc.org.
3
Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, 777 Bannock Street, MC 0180, Denver, CO, 80204, USA. Electronic address: erin.martinez@rmpdc.org.
4
Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, 777 Bannock Street, MC 0180, Denver, CO, 80204, USA. Electronic address: Becki.Bucher-Bartelson@rmpdc.org.
5
Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, 777 Bannock Street, MC 0180, Denver, CO, 80204, USA. Electronic address: marie-claire.lelait@rmpdc.org.
6
Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, 777 Bannock Street, MC 0180, Denver, CO, 80204, USA. Electronic address: jody.green@rmpdc.org.
7
Venebio Group, LLC, 7400 Beaufont Springs Drive, Suite 300, Richmond, VA 23225, USA. Electronic address: lenn.murrelle@venebio.com.
8
Department of Psychiatry, Washington University in St. Louis, One Brookings Drive, Campus Box 8134, St. Louis, MO 63130 USA. Electronic address: cicerot@psychiatry.wustl.edu.
9
Center for Applied Research on Substance Use and Health Disparities, Nova Southeastern University, 2 NE 40th Street, Suite 404, Miami, FL 33137 USA. Electronic address: steven.kurtz@nova.edu.
10
Institute for Treatment and Services Research, National Development and Research Institutes, 71 West 23rd Street, 4th floor, New York, NY 10010 USA. Electronic address: rosenblum@ndri.org.
11
Center for Applied Research on Substance Use and Health Disparities, Nova Southeastern University, 2 NE 40th Street, Suite 404, Miami, FL 33137 USA. Electronic address: surratt@nova.edu.
12
Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, 777 Bannock Street, MC 0180, Denver, CO, 80204, USA. Electronic address: richard.dart@rmpdc.org.

Abstract

Buprenorphine abuse is common worldwide. Rates of abuse and diversion of three sublingual buprenorphine formulations (single ingredient tablets; naloxone combination tablets and film) were compared. Data were obtained from the Researched Abuse, Diversion, and Addiction-Related Surveillance (RADARS) System Poison Center, Drug Diversion, Opioid Treatment (OTP), Survey of Key Informants' Patients (SKIP), and College Survey Programs through December 2012. To control for drug availability, event ratios (rates) were calculated quarterly, based on the number of patients filling prescriptions for each formulation ("unique recipients of a dispensed drug," URDD) and averaged and compared using negative binomial regression. Abuse rates in the OTP, SKIP, and College Survey Programs were greatest for single ingredient tablets, and abuse rates in the Poison Center Program and illicit diversion rates were greatest for the combination tablets. Combination film rates were significantly less than rates for either tablet formulation in all programs. No geographic pattern could be discerned.

KEYWORDS:

Buprenorphine; Drug abuse; Drug formulations; Substance-related disorders

PMID:
24680219
DOI:
10.1016/j.jsat.2014.02.003
[Indexed for MEDLINE]
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