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Trends Endocrinol Metab. 2014 May;25(5):263-73. doi: 10.1016/j.tem.2014.02.001. Epub 2014 Mar 26.

Maternal choline supplementation: a nutritional approach for improving offspring health?

Author information

1
Department of Health and Nutrition Sciences, Brooklyn College, Brooklyn, NY 11210, USA.
2
Division of Nutritional Sciences, Cornell University, Ithaca 14853, NY, USA.
3
Division of Nutritional Sciences, Cornell University, Ithaca 14853, NY, USA. Electronic address: mac379@cornell.edu.

Abstract

The modulatory role of choline on the fetal epigenome and the impact of in utero choline supply on fetal programming and health are of great interest. Studies in animals and/or humans suggest that maternal choline supplementation during pregnancy benefits important physiologic systems such as offspring cognitive function, response to stress, and cerebral inhibition. Because alterations in offspring phenotype frequently coincide with epigenetic modifications and changes in gene expression, maternal choline supplementation may be a nutritional strategy to improve lifelong health of the child. Future studies are warranted to elucidate further the effect of choline on the fetal epigenome and to determine the level of maternal choline intake required for optimal offspring physiologic function.

KEYWORDS:

choline; development; epigenetics; fetus; programming

PMID:
24680198
DOI:
10.1016/j.tem.2014.02.001
[Indexed for MEDLINE]

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