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Crit Rev Oncol Hematol. 2014 Aug;91(2):123-9. doi: 10.1016/j.critrevonc.2014.02.007. Epub 2014 Mar 12.

Oral manifestations in patients with neurofibromatosis type-1: a comprehensive literature review.

Author information

1
Eng. A. B. Research Chair for Growth Factors and Bone Regeneration, 3D Imaging and Biomechanical Laboratory, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia. Electronic address: fawjav@gmail.com.
2
Department of Oral and Maxillofacial Surgery, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
3
Department of Dentistry, Al-Farabi Dental College, Riyadh, Saudi Arabia.
4
Department of Community Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
5
Dental Public Health Department, Elite Medical and Surgical Center, Riyadh, Saudi Arabia.
6
Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge, Sweden.
7
Eng. A. B. Research Chair for Growth Factors and Bone Regeneration, 3D Imaging and Biomechanical Laboratory, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
8
Department of Clinical Affairs, School of Dental Medicine, Stony Brook University, Stony Brook, NY, USA.

Abstract

Oral health status is jeopardized in patients with neurofibromatosis (NF) type-1 (NF-1). The aim of the present study was to comprehensively review the oral manifestations in NF-1 patients. PubMed/Medline and Google-Scholar databases were explored using different keywords. Reviews, commentaries, letters to Editor and articles published in languages other than English were excluded.

RESULTS:

Neurofibromas of oral and perioral soft tissues with subsequent periodontitis, impacted and supernumerary teeth, enlarged alveolar process with dental spacing, morphological changes in teeth and class III molar relationship have been reported in NF-1 patients. Plexiform neurofibromas were reported both in oral soft tissue, maxilla and mandible with evidence of malignant transformation in some cases. Facial skeletal abnormalities, including enlargement of mandibular foramen, increased dimensions of the coronoid and sigmoid notches and notching of the posterior border of the mandible have also been reported. Association between dental caries and NF-1 remains unclear.

KEYWORDS:

Dental; Inflammation; Neurofibromatosis type-I; Oral and periodontal

[Indexed for MEDLINE]

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