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Cell. 2014 Mar 27;157(1):142-50. doi: 10.1016/j.cell.2014.02.032.

The virome in mammalian physiology and disease.

Author information

1
Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St. Louis, MO 63110, USA. Electronic address: virgin@wustl.edu.

Abstract

The virome contains the most abundant and fastest mutating genetic elements on Earth. The mammalian virome is constituted of viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect the broad array of other types of organisms that inhabit us. Virome interactions with the host cannot be encompassed by a monotheistic view of viruses as pathogens. Instead, the genetic and transcriptional identity of mammals is defined in part by our coevolved virome, a concept with profound implications for understanding health and disease.

PMID:
24679532
PMCID:
PMC3977141
DOI:
10.1016/j.cell.2014.02.032
[Indexed for MEDLINE]
Free PMC Article

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