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Cell. 2014 Mar 27;157(1):110-9. doi: 10.1016/j.cell.2014.02.041.

Rethinking differentiation: stem cells, regeneration, and plasticity.

Author information

1
Stowers Institute for Medical Research and Howard Hughes Medical Institute, Kansas City, MO 64110, USA. Electronic address: asa@stowers.org.
2
Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA. Electronic address: yamanaka@cira.kyoto-u.ac.jp.

Abstract

Cell differentiation is an essential process for the development, growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the focus of intense investigation for the past four decades. The study of natural and induced stem cells has ushered an age of re-examination of what it means to be a stem or a differentiated cell. Past and recent discoveries in plants and animals, as well as novel experimental manipulations, are beginning to erode many of these established concepts and are forcing a re-evaluation of the experimental systems and paradigms presently being used to explore these and other biological process.

PMID:
24679530
PMCID:
PMC4074550
DOI:
10.1016/j.cell.2014.02.041
[Indexed for MEDLINE]
Free PMC Article

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