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Trends Cell Biol. 2014 Apr;24(4):209-11. doi: 10.1016/j.tcb.2014.02.002.

Manipulating mitochondrial genomes in the clinic: playing by different rules.

Author information

1
University of Miami Miller School of Medicine, Department of Neurology and Cell Biology, 1420 NW 9th Avenue, Rm 229, Miami, FL 33136, USA. Electronic address: cmoraes@med.miami.edu.
2
University of Miami Miller School of Medicine, Department of Neurology and Cell Biology, 1420 NW 9th Avenue, Rm 229, Miami, FL 33136, USA.

Abstract

Recently, several publications have surfaced describing methods to manipulate mitochondrial genomes in tissues and embryos. With them, a somewhat sensationalistic uproar about the generation of children with 'three parents' has dominated the discussion in the lay media. It is important that society understands the singularities of mitochondrial genetics to judge these procedures in a rational light, so that this ongoing discussion does not preclude the helping of patients and families harboring mutated mitochondrial genomes.

PMID:
24679453
PMCID:
PMC4274037
DOI:
10.1016/j.tcb.2014.02.002
[Indexed for MEDLINE]
Free PMC Article

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