Format

Send to

Choose Destination
Trends Immunol. 2014 May;35(5):205-10. doi: 10.1016/j.it.2014.02.009. Epub 2014 Mar 26.

The establishment of B versus T cell identity.

Author information

1
Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA.
2
Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: murre@biomail.ucsd.edu.

Abstract

In B cell progenitors, E-proteins E2A and HEB (HeLa E-box binding protein) are crucial for the induction of a B lineage-specific program of gene expression and for orchestrating the assembly of the immunoglobulin loci. In the thymus E2A and HEB act differently, activating the expression of genes closely associated with the establishment of T cell identity and promoting the rearrangement of T cell receptor (TCR) loci. These findings have raised the question as to how E-proteins exert these different activities. We review here the distinct regulatory networks that establish B versus T cell identity, and how genomic architecture and location of genes is modulated in these lineage decisions. We conclude by proposing a model wherein stochasticity in the nuclear location of the early B cell factor 1 (Ebf1) locus in multipotent progenitors determines this lineage choice.

PMID:
24679436
PMCID:
PMC4030559
DOI:
10.1016/j.it.2014.02.009
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center