Send to

Choose Destination
J Exerc Rehabil. 2014 Feb 28;10(1):15-21. doi: 10.12965/jer.140088. eCollection 2014 Feb.

Treadmill exercise enhances NMDA receptor expression in schizophrenia mice.

Author information

Division of Exercise and Health Science, College of Arts and Physical Education, Incheon National University, Incheon, Korea.
Department of Physical Education, College of Health, Welfare, and Education, Tong Myong University, Busan, Korea.
Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.


Schizophrenia is a serious psychiatric disorder with several symptoms including cognitive dysfunction. Although the causes of schizophrenia are still unclear, there is a strong suspicion that the abnormality in N-methyl-D-aspartate (NMDA) receptor may contribute to schizophrenia symptoms. In the present study, the effect of treadmill exercise on the NMDA receptor expression was evaluated using MK-801-induced schizophrenia mice. Immunohistochemistry for expressions of NMDA receptor tyrosine hydroxylase (TH) was conducted. Western blot for brain-derived neurotrophic factor (BDNF) was also performed. In the present results, the mice in the MK-801-treated group displayed reduced NMDA receptor expression. Enhanced TH expression and suppressed BDNF expression were also observed in the MK-801-treated mice. Treadmill exercise improved NMDA receptor expression in the MK-801-induced schizophrenia mice. Treadmill exercise also suppressed TH expression and enhanced BDNF expression in the MK-801-induced schizophrenia mice. The present study showed that down-regulation of NMDA receptor demonstrated schizophrenia-like parameters, meanwhile treadmill running improved schizophrenia-related parameters through enhancing NMDA receptor expression.


Brain-derived neurotrophic factor; N-methyl-D-aspartate receptor; Schizophrenia; Treadmill exercise; Tyrosine hydroxylase

Supplemental Content

Full text links

Icon for Korean Society of Exercise Rehabilitation Icon for PubMed Central
Loading ...
Support Center