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ScientificWorldJournal. 2014 Feb 11;2014:898361. doi: 10.1155/2014/898361. eCollection 2014.

Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial.

Author information

1
Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ; Department of Biotechnology, Science & Research Branch, Islamic Azad University, Tehran, Iran.
2
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ; Neurogenic Inflammation Research Centre, Department of Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran.
3
Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ; Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5
Department of Plant Breeding, Science & Research Branch, Islamic Azad University, Tehran, Iran.
6
Deputy of Research, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
7
Division of Medical Education, Mayfield House, University of Brighton, Room 342, Brighton BN1 9PH, UK.
8
Biochemistry of Nutrition Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

BACKGROUND:

Obesity is a disorder often accompanied by a heightened state of systemic inflammation and immunoactivation. The present randomized crossover trial aimed to investigate the efficacy of curcumin, a bioactive polyphenol with established anti-inflammatory and immunomodulatory effects, on the serum levels of a panel of cytokines and mediators in obese individuals.

METHODS:

Thirty obese individuals were randomized to receive curcumin at a daily dose of 1 g or a matched placebo for 4 weeks. Following a 2-week wash-out period, each group was assigned to the alternate treatment regimen for another 4 weeks. Serum samples were collected at the start and end of each study period. Serum levels of IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFNγ, EGF, MCP-1, and TNF α were measured using a multiplex Biochip Array Technology based method.

RESULTS:

Mean serum IL-1β (P = 0.042), IL-4 (P = 0.008), and VEGF (P = 0.01) were found to be significantly reduced by curcumin therapy. In contrast, no significant difference was observed in the concentrations of IL-2, IL-6, IL-8, IL-10, IFNγ, EGF, and MCP-1.

CONCLUSIONS:

The findings of the present trial suggested that curcumin may exert immunomodulatory effects via altering the circulating concentrations of IL-1β, IL-4, and VEGF.

PMID:
24678280
PMCID:
PMC3942342
DOI:
10.1155/2014/898361
[Indexed for MEDLINE]
Free PMC Article

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