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Birth Defects Res C Embryo Today. 2014 Mar;102(1):37-51. doi: 10.1002/bdrc.21058.

TGFβ signaling in cartilage development and maintenance.

Author information

1
Department of Orthopaedic Surgery and Orthopaedic Institute for Children, David Geffen School of Medicine, University of California, Los Angeles, California, 90095.

Abstract

Members of the transforming growth factor beta (TGFβ) superfamily of secreted factors play essential roles in nearly every aspect of cartilage formation and maintenance. However, the mechanisms by which TGFβs transduce their effects in cartilage in vivo remain poorly understood. Mutations in several TGFβ family members, their receptors, extracellular modulators, and intracellular transducers have been described, and these usually impact the development of the cartilaginous skeleton. Furthermore, genome-wide association studies have linked components of the (TGFβ) superfamily to susceptibility to osteoarthritis. This review focuses on recent discoveries from genetic studies in the mouse regarding the regulation of TGFβ signaling in developing growth plate and articular cartilage, as well as the different modes of crosstalk between canonical and noncanonical TGFβ signaling. These new insights into TGFβ signaling in cartilage may open new prospects for therapies that maintain healthy articular cartilage.

KEYWORDS:

TGFβ; cartilage; development; maintenance; signaling

PMID:
24677722
PMCID:
PMC4267887
DOI:
10.1002/bdrc.21058
[Indexed for MEDLINE]
Free PMC Article
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