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Blood. 2014 Mar 27;123(13):1975-6. doi: 10.1182/blood-2014-02-555805.

New anti-complement drugs: not so far away.

Author information

1
UNIVERSITY OF COLORADO DENVER.

Abstract

In this issue of Blood, Risitano et al demonstrate that small-molecule inhibitors of C3 cleavage prevent complement activation on erythrocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH); the authors demonstrate that these agents reach therapeutic concentrations after subcutaneous injection in nonhuman primates.

PMID:
24677397
PMCID:
PMC3968382
DOI:
10.1182/blood-2014-02-555805
[Indexed for MEDLINE]
Free PMC Article

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