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Br J Psychiatry. 2014 Jun;204(6):486-7. doi: 10.1192/bjp.bp.113.132977. Epub 2014 Mar 27.

Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD.

Author information

1
Cleo L. Crunelle, PhD, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Belgium; Amsterdam Institute for Addiction Research and Departments of Psychiatry and Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands; Wim van den Brink, MD, PhD, Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands; Geert Dom, MD, PhD, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, and Psychiatric Centre Alexian Brothers, Boechout, Belgium; Jan Booij, MD, PhD, Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.

Abstract

Impulsivity is a multidimensional construct, including impulsive decision-making and impulsive action, representing relatively independent neurocircuitries. ADHD is treated with methylphenidate, a drug that binds to dopamine transporters. This study in 24 adult male patients with ADHD shows that dopamine transporter occupancy by methylphenidate in the putamen correlates with improvements in cognitive but not in motor impulsivity.

PMID:
24676965
DOI:
10.1192/bjp.bp.113.132977
[Indexed for MEDLINE]

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