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Oncol Rep. 2014 May;31(5):2407-12. doi: 10.3892/or.2014.3108. Epub 2014 Mar 21.

Assessment of tumor size as a useful marker for the surgical staging of endometrial cancer.

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Department of Surgical Sciences, University of Parma, Parma, Italy.
Department of Women and Child Health, University of Padua, Padua, Italy.


Accumulating evidence suggests that the estimation of tumor size may improve endometrial cancer treatment. We conducted an observational study aimed at elucidating the association between tumor size and other universally accepted prognostic factors in order to identify suitable preoperative parameters which can guide surgery in a subgroup of early corpus endometrial cancer. We found that when tumor size increased, both stage and grading were significantly increased. Tumor size was correlated with CA 125 serum values, node metastasis and peritoneal cytology status. Patients who have grade 1 or 2 endometrioid corpus cancer, myometrial invasion < 50% and ≤ 3 cm largest tumor diameter can only be treated with hysterectomy. The tumor largest diameter should be evaluated as a preoperative parameter that indicates patients who do not require lymphadenectomy.

[Indexed for MEDLINE]

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