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Science. 2014 Mar 28;343(6178):1485-1489. doi: 10.1126/science.1249410.

Structure of the yeast mitochondrial large ribosomal subunit.

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1
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom.
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Contributed equally

Abstract

Mitochondria have specialized ribosomes that have diverged from their bacterial and cytoplasmic counterparts. We have solved the structure of the yeast mitoribosomal large subunit using single-particle cryo-electron microscopy. The resolution of 3.2 angstroms enabled a nearly complete atomic model to be built de novo and refined, including 39 proteins, 13 of which are unique to mitochondria, as well as expansion segments of mitoribosomal RNA. The structure reveals a new exit tunnel path and architecture, unique elements of the E site, and a putative membrane docking site.

PMID:
24675956
PMCID:
PMC4046073
DOI:
10.1126/science.1249410
[Indexed for MEDLINE]
Free PMC Article
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