Format

Send to

Choose Destination
PLoS One. 2014 Mar 27;9(3):e92877. doi: 10.1371/journal.pone.0092877. eCollection 2014.

The Geogenomic Mutational Atlas of Pathogens (GoMAP) web system.

Author information

1
School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, United States of America.

Abstract

We present a new approach for pathogen surveillance we call Geogenomics. Geogenomics examines the geographic distribution of the genomes of pathogens, with a particular emphasis on those mutations that give rise to drug resistance. We engineered a new web system called Geogenomic Mutational Atlas of Pathogens (GoMAP) that enables investigation of the global distribution of individual drug resistance mutations. As a test case we examined mutations associated with HIV resistance to FDA-approved antiretroviral drugs. GoMAP-HIV makes use of existing public drug resistance and HIV protein sequence data to examine the distribution of 872 drug resistance mutations in ∼ 502,000 sequences for many countries in the world. We also implemented a broadened classification scheme for HIV drug resistance mutations. Several patterns for geographic distributions of resistance mutations were identified by visual mining using this web tool. GoMAP-HIV is an open access web application available at http://www.bio-toolkit.com/GoMap/project/.

PMID:
24675726
PMCID:
PMC3968042
DOI:
10.1371/journal.pone.0092877
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center