World atlas displays showing observation of DRMs derived from patient blood samples for naïve (A) and treated (B) patients. The examples shown are for the beneficial N88S DRM for Fosamprenavir. A color legend for country coloring is shown (bottom).

A. The Country Selection window is used to load data into world atlas displays and populate the Drug Selection table. B. The Drug Selection window is for choosing an FDA-approved drug. ARVs are grouped by type: Protease inhibitors (PI) are colored a light blue, nucleoside/nucleotide reverse transcriptase inhibitors (NRTI) are tan, non-nucleoside reverse transcriptase inhibitors (NNRTI) are coral, integrase inhibitors (II) are light green, and fusion inhibitors (FI) are light magenta. The number of different patient blood samples for a country selected in A is shown. If the “Select All Countries” checkbox is checked, data for all countries are shown. Selection of a drug populates the DRM Selection table with DRM data for that drug, and country if selected. C. The DRM Selection table shows DRMs ordered by their classification. Once a DRM is selected (N88S here) the presence of DRMs in each country are plotted onto the world atlases and the DRM Observation By Country table (D) is populated. The DRM Selection table also has a hyperlink to one or more published papers supporting the DRM. Checkboxes below the title bar enable display of DRMs present in other databases for which no published scientific paper could be identified (designated ambiguous), for showing the Major/Minor DRM classification scheme, and for examining DRMs only in the country selected. D. The DRM Observation By Country table shows a list of the observed DRMs (numerator) and total sequences examined (denominator) for each country. The data are stratified for naïve and treated patients.

Atlas displays for all 12 beneficial, primary, and primary set DRMs in the protease gene associated with Fosamprenavir and only for patient blood samples from drug-experienced patients (A-L). DRM type labels are colored as in the DRM table ().

Atlas displays for all 12 beneficial, primary, and primary set DRMs in the protease gene associated with Fosamprenavir and only for patient blood samples sequences from naïve patients (A-L). DRM type labels are colored as in .