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Am J Forensic Med Pathol. 1988 Dec;9(4):310-2.

Aging of wound healing in an experimental model in mice.

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Greenberg Institute of Forensic Medicine, Chaim Sheba Medical Center, Tel-Hashomer, Israel.


Healing of incised wounds in the backs of mice was studied to establish criteria that would allow the timing of stages during cutaneous wound healing. Starting from day 4 after the incisions were made, three mice were killed every 3 days until day 40. Sections from wounds were stained with hematoxylin-eosin, a reticulin procedure, and picrosirius red. Unstained sections were used for blue autofluorescence. The significance of the findings from the ultraviolet study was limited, but the picrosirius red-polarized light procedure was found to be useful for estimating the age of the repair process as polarization colors of greater wavelengths progressively increased with the age of the lesion.

[Indexed for MEDLINE]

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