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Nat Genet. 2014 Apr;46(4):321-3. doi: 10.1038/ng.2930.

Ancient human oral plaque preserves a wealth of biological data.

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1
BioFrontiers Institute, University of Colorado at Boulder, Boulder, Colorado, USA.

Abstract

A new study explores the ancient oral microbiome from the well-preserved dental calculus samples of four human individuals who lived during medieval times, using a suite of genomic, proteomic and microscopic approaches. The authors investigate the evolution of dental pathogens by reconstructing the genome of the periodontal pathogen Tannerella forsythia and also identify antibiotic resistance genes, bacterial virulence factors and host immune defense proteins.

PMID:
24675519
DOI:
10.1038/ng.2930
[Indexed for MEDLINE]
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