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Oncotarget. 2014 Mar 15;5(5):1132-48.

Heat shock proteins in multiple myeloma.

Abstract

Heat shock proteins are molecular chaperones with a central role in protein folding and cellular protein homeostasis. They also play major roles in the development of cancer and in recent years have emerged as promising therapeutic targets. In this review, we discuss the known molecular mechanisms of various heat shock protein families and their involvement in cancer and in particular, multiple myeloma. In addition, we address the current progress and challenges in pharmacologically targeting these proteins as anti-cancer therapeutic strategies.

PMID:
24675290
PMCID:
PMC4012740
DOI:
10.18632/oncotarget.1584
[Indexed for MEDLINE]
Free PMC Article

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