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Nephrol Dial Transplant. 2014 Oct;29(10):1821-7. doi: 10.1093/ndt/gfu026. Epub 2014 Mar 27.

Epigenetics: a new way to look at kidney diseases.

Author information

1
Renal Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Abstract

Only a few percent of the 3 billion pairs of chemical letters in the human genome is responsible for protein-coding sequences. Recent advances in the field of epigenomics have helped us to understand how most of the remaining sequences are responsible for gene regulation at baseline and in disease conditions. Here we discuss recent advances in the area of epigenetics--specifically in cytosine modifications--and its application in the field of nephrology.

KEYWORDS:

chronic kidney disease; cytosine methylation; enhancers; epigenetics

PMID:
24675284
PMCID:
PMC4173816
DOI:
10.1093/ndt/gfu026
[Indexed for MEDLINE]
Free PMC Article

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