Format

Send to

Choose Destination
See comment in PubMed Commons below
Science. 2014 Apr 25;344(6182):386-92. doi: 10.1126/science.1250298. Epub 2014 Mar 27.

Discovery of brainwide neural-behavioral maps via multiscale unsupervised structure learning.

Author information

1
Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

Abstract

A single nervous system can generate many distinct motor patterns. Identifying which neurons and circuits control which behaviors has been a laborious piecemeal process, usually for one observer-defined behavior at a time. We present a fundamentally different approach to neuron-behavior mapping. We optogenetically activated 1054 identified neuron lines in Drosophila larvae and tracked the behavioral responses from 37,780 animals. Application of multiscale unsupervised structure learning methods to the behavioral data enabled us to identify 29 discrete, statistically distinguishable, observer-unbiased behavioral phenotypes. Mapping the neural lines to the behavior(s) they evoke provides a behavioral reference atlas for neuron subsets covering a large fraction of larval neurons. This atlas is a starting point for connectivity- and activity-mapping studies to further investigate the mechanisms by which neurons mediate diverse behaviors.

PMID:
24674869
DOI:
10.1126/science.1250298
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center