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Trends Biochem Sci. 2014 Apr;39(4):170-82. doi: 10.1016/j.tibs.2014.02.007. Epub 2014 Mar 24.

Enhancer RNAs and regulated transcriptional programs.

Author information

1
Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
2
Howard Hughes Medical Institute, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
3
Howard Hughes Medical Institute, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA. Electronic address: mrosenfeld@ucsd.edu.
4
Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA; Howard Hughes Medical Institute, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA. Electronic address: ckg@ucsd.edu.

Abstract

A large portion of the human genome is transcribed into RNAs without known protein-coding functions, far outnumbering coding transcription units. Extensive studies of long noncoding RNAs (lncRNAs) have clearly demonstrated that they can play critical roles in regulating gene expression, development, and diseases, acting both as transcriptional activators and repressors. More recently, enhancers have been found to be broadly transcribed, resulting in the production of enhancer-derived RNAs, or eRNAs. Here, we review emerging evidence suggesting that at least some eRNAs contribute to enhancer function. We discuss these findings with respect to potential mechanisms of action of eRNAs and other ncRNAs in regulated gene expression.

KEYWORDS:

eRNA; enhancer; noncoding RNA; transcription

PMID:
24674738
PMCID:
PMC4266492
DOI:
10.1016/j.tibs.2014.02.007
[Indexed for MEDLINE]
Free PMC Article

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