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Asia Pac J Clin Oncol. 2016 Jun;12(2):e352-e355. doi: 10.1111/ajco.12184. Epub 2014 Mar 27.

Adenoid cystic carcinoma of the lung: Response to tamoxifen after chemoradiation.

Liu J1,2, Hau E1,3, Links M1,3, Graham PH1,3.

Author information

  • 1Faculty of Medicine, University of NSW, New South Wales, Australia.
  • 2Prince of Wales Clinical School, University of NSW, New South Wales, Australia.
  • 3Department of Radiation Oncology, Cancer Care Centre, St George Hospital, New South Wales, Australia.

Abstract

Primary adenoid cystic carcinoma of the lung is a rare subtype of lung cancer with a prolonged natural history but is difficult to completely resect surgically due to its proximal location. Hence radiotherapy plays a role for local control of these cancers. The role of systemic therapies in the treatment of adenoid cystic carcinoma of the lung remains unclear. Isolated case reports have previously described the treatment of primary adenoid cystic carcinoma of the lung with tamoxifen, resulting in partial control. We report the first case of primary adenoid cystic carcinoma of the lung treated with primary chemoradiotherapy due to unresectable location of the tumor, and disease stabilization with symptomatic response to tamoxifen following tumor recurrence. There is a need for further studies to investigate the role of anti-hormonal therapies in the treatment of adenoid cystic carcinoma of the lung.

PMID:
24673873
DOI:
10.1111/ajco.12184
[PubMed - as supplied by publisher]
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