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Nutr Metab (Lond). 2014 Mar 28;11:15. doi: 10.1186/1743-7075-11-15. eCollection 2014.

Coacervate whey protein improves inflammatory milieu in mice fed with high-fat diet.

Author information

1
Departamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
2
Instituto de Ciências e Tecnologia da Universidade Federal de São Paulo, São José dos Campos, SP, Brazil.

Abstract

BACKGROUND:

Functional foods with bioactive properties may help in treat obesity, as they can lead to a decreased risks of inflammatory diseases. The aim of this study was to investigate the effects of chitosan coacervate whey protein on the proinflammatory processes in mice fed with high-fat diet.

METHODS:

Mice were divided into two groups receiving either a normolipidic or high-fat diet; the animals in each of the two diet groups were given a diet supplement of either coacervate (gavage, 36 mg protein/kg of body weight) or tap water for four weeks [groups: normolipidic diet plus water (C); normolipidic diet and coacervate (CC); high-fat diet and water (H); and high-fat diet and coacervate (HC)].

RESULTS:

The high-fat diet promoted inflammation, possibly by decreased adiponectin/sum of adipose tissues ratio and increased phosphorylation of NF-κB p50. In HC we observed a positive correlation between IL-10 and TNF-α in mesenteric adipose tissue, retroperitoneal adipose tissue and liver tissue. We also observed a positive correlation between lipopolisaccharide with IL-10 in the liver tissue.

CONCLUSIONS:

High-fat diet treatment promoted metabolic alterations and inflammation, and chitosan coacervate whey protein modulated inflammatory milieu.

KEYWORDS:

Cytokines; IL-10; Mesenteric adipose tissue

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