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Gut Liver. 2014 Mar;8(2):215-8. doi: 10.5009/gnl.2014.8.2.215. Epub 2013 Nov 5.

Severe bleeding and perforation are rare complications of endoscopic ultrasound-guided fine needle aspiration for pancreatic masses: an analysis of 3,090 patients from 212 hospitals.

Author information

1
Department of Gastroenterology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
2
Department of Health Economics and Epidemiology Research, The University of Tokyo School of Public Health, Tokyo, Japan.
3
Department of Clinical Data Management and Research, Clinical Research Center, National Hospital Organization Headquarters, Tokyo, Japan.
4
Department of Health Care Informatics, Tokyo Medical and Dental University, Tokyo, Japan.
5
Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Kitakyushu, Japan.

Abstract

BACKGROUND/AIMS:

Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is useful for the pathological diagnosis of pancreatic masses, but patients are susceptible to severe bleeding and perforation. Because the incidence and severity of these complications have not been fully evaluated.

METHODS:

We aimed to evaluate severe bleeding and perforation after EUS-FNA for pancreatic masses using large-scale data derived from a Japanese nationwide administrative database.

RESULTS:

In total, 3,090 consecutive patients from 212 low- to high-volume hospitals were analyzed. Severe bleeding requiring transfusion or endoscopic treatment occurred in seven patients (0.23%), and no perforation was observed. No patient mortality was recorded within 30 days of EUS-FNA. The rate of severe bleeding in low-volume hospitals was significantly higher than that in medium- and high-volume hospitals (0.48% vs 0.10%, p=0.045).

CONCLUSIONS:

Severe bleeding and perforation following EUS-FNA for pancreatic masses are rare, and the procedure is safe.

KEYWORDS:

Endoscopic ultrasound-guided fine needle aspiration; Hemorrhage; Pancreas; Perforation

PMID:
24672664
PMCID:
PMC3964273
DOI:
10.5009/gnl.2014.8.2.215
[Indexed for MEDLINE]
Free PMC Article

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