Send to

Choose Destination
See comment in PubMed Commons below
J Hum Reprod Sci. 2013 Oct;6(4):227-34. doi: 10.4103/0974-1208.126285.

Luteinizing hormone and follicle stimulating hormone synergy: A review of role in controlled ovarian hyper-stimulation.

Author information

  • 1Division of Gynaecology, Krishna IVF Clinic, Visakhapatnam, India.
  • 2Department of Pharmacology Medical Affairs, Merck Specialities Private Limited, Mumbai, Maharashtra, India.
  • 3Department of Reproductive medicine, Infertility Institute and Research Centre, Secunderabad, Andhra Pradesh, India.
  • 4Department of Obstetrics, Gynaecology & Infertility, Gunasheela Assisted Reproduction Centre, Bengaluru, Karnataka, India.
  • 5Department of Reproductive Medicine, NOVA IVI Fertility, Kolkata, West Bengal, India.
  • 6Department of Reproductive Medicine, Prashanth Fertility Research Centre, Chennai, India.
  • 7Department of Obstetrics, Gynaecology & Reproductive Medicine, Womens Center and Hospitals, Coimbatore, Tamil Nadu, India.
  • 8Department of Infertility, Akanksha IVF, Anand, Gujarat, India.
  • 9Department of Assisted Reproduction, Fertility Associates, Mumbai, Maharashtra, India.


Luteinizing hormone (LH) in synergy with follicle stimulating hormone (FSH) stimulates normal follicular growth and ovulation. FSH is frequently used in assisted reproductive technology (ART). Recent studies have facilitated better understanding on the complementary role of the LH to FSH in regulation of the follicle; however, role of LH in stimulation of follicle, optimal dosage of LH in stimulation and its importance in advanced aged patients has been a topic of discussion among medical fraternity. Though the administration of exogenous LH with FSH is obligatory for controlled ovarian stimulation in patients with hypogonadotropic hypogonadism, there is still a paucity of information of its usage in other patient population. In this review we looked in to the multiple roles that LH plays complementary to FSH to better understand the LH requirement in patients undergoing ART.


Assisted reproductive techniques; follicle stimulating hormone; luteinizing hormone; ovarian hyper-stimulation


Publication Types

Publication Types

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
    Loading ...
    Support Center