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Sci Transl Med. 2014 Mar 26;6(229):229le2. doi: 10.1126/scitranslmed.3008763.

Comment on "drug discovery: turning the titanic".

Author information

1
School of Medicine and Pharmacology and National Centre for Asbestos Related Diseases, University of Western Australia, Harry Perkins Institute of Medical Research, 5th Floor, QQ Block, 6 Verdun Street, Nedlands, Perth, Western Australia 6009, Australia.

Abstract

The pathobiology-based approach to research and development has been the dominant paradigm for successful drug discovery over the last decades. We propose that the molecular and cellular events that govern a resolving, rather than an evolving, disease may reveal new druggable pathways.

Comment on

PMID:
24670682
DOI:
10.1126/scitranslmed.3008763
[Indexed for MEDLINE]
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