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Mod Rheumatol. 2014 Nov;24(6):926-30. doi: 10.3109/14397595.2014.891495. Epub 2014 Mar 26.

Identification of clinical parameters associated with serum oxidative stress in patients with rheumatoid arthritis.

Author information

1
Department of Orthopedics, Toho University Sakura Medical Center , Sakura, Chiba , Japan.

Abstract

OBJECTIVES:

Reactive oxygen species (ROS) are considered to be involved in the pathobiology of rheumatoid arthritis (RA); however, their association with disease activity has not been elucidated. In this study, we measured reactive oxygen metabolites (ROM) in patients with RA using a new Free Radical Analytical System and determined clinical parameters associated with ROM.

METHODS:

One hundred and fifty-two patients with RA and 80 patients with diabetes mellitus (DM) were included in this observational study. To measure ROM, the d-ROM test was performed on blood samples drawn from all subjects. The correlation between ROM and biomarkers, disease activity, doses of methotrexate (MTX), and prednisolone (PSL) were investigated.

RESULTS:

There were significant, positive correlations between ROM and CRP, matrix metalloproteinase 3 (MMP3), Disease Activity Score 28-erythrocyte sedimentation rate (DAS28-ESR), Clinical Disease Activity Index (CDAI), and the Simplified Disease Activity Index (SDAI). Multiple regression analysis revealed that CRP and DAS28-ESR were correlated with ROM.

CONCLUSIONS:

The serum level of ROM was associated with CRP and DAS28-ESR, suggesting that ROM, in conjunction with CRP and MMP3, may be able to be used as a new biological disease marker to evaluate the disease activity of RA.

KEYWORDS:

Disease activity; Oxidative stress; Reactive oxygen metabolites; Rheumatoid arthritis

PMID:
24670128
DOI:
10.3109/14397595.2014.891495
[Indexed for MEDLINE]

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