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ACS Comb Sci. 2014 May 12;16(5):238-43. doi: 10.1021/co4001524. Epub 2014 Apr 4.

Efficient synthesis of functionalized benzo[b][1,8]naphthyridine derivatives via three-component reaction catalyzed by L-proline.

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1
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, P. R. China.

Abstract

A facile and efficient one-pot procedure for the preparation of functionalized benzo[b][1,8]naphthyridine derivatives by three-component reaction of 2-chloroquinoline-3-carbaldehyde, 1,3-dicarbonyl compounds, and enaminones catalyzed by l-proline is described. This new protocol has the advantages of environmental friendliness, good yields, and convenient operation.

KEYWORDS:

benzo[b][1,8]naphthyridine; l-proline; three-component reaction

PMID:
24669887
DOI:
10.1021/co4001524
[Indexed for MEDLINE]
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