Send to

Choose Destination
Exp Ther Med. 2014 Apr;7(4):773-777. Epub 2014 Jan 23.

Exercise upregulates salivary amylase in humans (Review).

Author information

Laboratory of Sports Nutrition and Biochemistry, Graduate School of Health and Sports Science, Juntendo University, Inzai, Chiba 270-1695, Japan.


The secretion of salivary α-amylase is influenced by adrenergic regulation of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis; thus, exercise affects the levels of salivary α-amylase. Granger et al published a review in 2007 that focused attention on salivary α-amylase. In addition, a portable system for monitoring salivary α-amylase activity was launched in Japan at the end of 2005. The correlation between exercise and salivary α-amylase has since been extensively investigated. The present review summarizes relevant studies published in the English and Japanese literature after 2006. A search of the PubMed and CiNii databases identified 54 articles, from which 15 original articles were selected. The findings described in these publications indicate that exercise consistently increases mean salivary α-amylase activities and concentrations, particularly at an intensity of >70% VO2max in healthy young individuals. Thus, these studies have confirmed that salivary α-amylase levels markedly increase in response to physical stress. Salivary α-amylase levels may therefore serve as an effective indicator in the non-invasive assessment of physical stress.


adrenergic; athlete; physical stress; sympathetic nervous system

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center